Comparative Clinical Characteristics Among Different Age Group of Adult COVID-19 Patients (preprint)

Introduction: Coronavirus disease (COVID-19) is a global infectious disease with a large burden of illness and high healthcare costs.Objectives: This study aimed to compare clinical features among adult COVID-19 patients in different age groups.Methods: Laboratory-confirmed adult COVID-19 infection cases between Dec 31, 2019 to March 8, 2020obtained from Neighboring Cities. Patients weredivided into five age groups:age＜30, 30-40, 40-50, 50-65, ≥65 y (elderly). Age, sex, history of chronic disease and epidemiology, symptoms, laboratory tests, and outcomes were compared among different agegroups. Binary logistic regression analysis was conducted to evaluate associated factors for severe or critical type.Results:We studied 299 cases. Median (IQR) age was 44(34,54) and 158 (53%) were male. Percent of bilateral involvement on chest radiographs was increased significantly with older age (p=0.005). 53.3% of 30-40 years, 50% of 40-50 years, 36.6% of ＜30 years and 36.2% of 50-60 years were imported case, none of the elderly were imported case. Among all the observed symptoms, only symptom of dyspnea was significantly different between the elderly group and other groups (p < 0.001).Proportion of severe or critical type was 2.4%, 5.3%, 9.5%, 14.5%, and 35%in patients with age＜30, 30-40, 40-50, 50-65, ≥65 (p < 0.001), respectively. At this point, ICU admissionrate, ARDSand shock rate and on medical treatment rate was increased especially in patients ≥65 years. 285 patients (95.3%) were curedand discharged, 12 patients (4.0%) were still on medical treatment in hospital. There were 2 (0.67%) deaths; these occurred among persons ≥65 y (p < 0.001). Old age, high HR on admission,high respiratory rate on admission, and history of chronic heart diseasewere independently associated with severe or critical .Conclusions:Proportion of severe or critical type increased with old age groups. Adults with old ageand high HR, R rate in admission and history of chronic heart disease were associated withsevere or criticaltype in COVID-19.

Comparative Clinical Characteristics Among Different Age Group of Adult COVID-19 Patients (preprint)

Introduction: Coronavirus disease (COVID-19) is a global infectious disease with a large burden of illness and high healthcare costs.Objectives: This study aimed to compare clinical features among adult COVID-19 patients in different age groups.Methods: Laboratory-confirmed adult COVID-19 infection cases between Dec 31, 2019 to March 8, 2020 obtained from Neighboring Cities. Patients were divided into five age groups: age༜30, 30–40, 40–50, 50–65, ≥ 65 y (elderly). Age, sex, history of chronic disease and epidemiology, symptoms, laboratory tests, and outcomes were compared among different age groups. Binary logistic regression analysis was conducted to evaluate associated factors for severe or critical type.Results: We studied 299 cases. Median (IQR) age was 44 (34,54) and 158 (53%) were male. Percent of bilateral involvement on chest radiographs was increased significantly with older age (p = 0.005). 53.3% of 30–40 years, 50% of 40–50 years, 36.6% of ༜30 years and 36.2% of 50–60 years were imported case, none of the elderly were imported case. Among all the observed symptoms, only symptom of dyspnea was significantly different between the elderly group and other groups (p < 0.001). Proportion of severe or critical type was 2.4%, 5.3%, 9.5%, 14.5%, and 35% in patients with age༜30, 30–40, 40–50, 50–65, ≥ 65 (p < 0.001), respectively. At this point, ICU admission rate, ARDS and shock rate and on medical treatment rate was increased especially in patients ≥ 65 years. 285 patients (95.3%) were cured and discharged, 12 patients (4.0%) were still on medical treatment in hospital. There were 2 (0.67%) deaths; these occurred among persons ≥ 65 y (p < 0.001). Old age, high HR on admission, high respiratory rate on admission, and history of chronic heart disease were independently associated with severe or critical .Conclusions: Proportion of severe or critical type increased with old age groups. Adults with old age and high HR, R rate in admission and history of chronic heart disease were associated with severe or critical type in COVID-19.

Symptoms at disease onset predict prognosis in COVID-19 disease (preprint)

Background: The main clinical manifestations of coronavirus disease 2019 (COVID-19) onset are respiratory symptoms, including cough, sputum and dyspnea. However, a significant proportion of patients initially manifested extra-respiratory symptoms, such as fever, myalgia and diarrhea. Here we compared the different characteristics and outcomes between the patients with respiratory symptoms and extra-respiratory symptoms at illness onset.Methods: The patients admitted to the respiratory departments from eight hospitals out of Wuhan with nucleic acid-positive of severe acute respiratory syndrome coronavirus (SARS-CoV-2) were recruited. Epidemiological information, clinical manifestations, laboratory findings, and radiological characteristics, treatment regimens and outcomes data were recorded and analyzed.Results: The median age of the recruited 541 subjects was 43 years (IQR, 33-55). Of the 541 subjects, 404 (74.5%) subjects had initial symptom that were respiratory, while 137 (25.5%) subjects had extra-respiratory symptoms. Respiratory COVID-19 subjects had more secondary bacterial infections (p<0.001), needed the intensive care unit more (p=0.005), non-invasive ventilation more (p=0.004), developed ARDS more (p=0.001) and needed longer to recover (p=0.003) compared to predominately extra-respiratory COVID-19 subjects. The multivariate model showed that age (OR = 1.04, p = 0.01) dyspnea (OR = 4.91, p < 0.001) and secondary bacterial infection (OR = 19.8, p < 0.001) were independently associated with development of ARDS among COVID-19 patients.Conclusion: we identify COVID-19 subjects with dyspnea at disease onset have worse prognosis. We also demonstrate age and secondary bacterial infections to be independently associated with ARDS development in subjects with COVID-19.

Comparative clinical characteristics among different age group of adult COVID-19 Patients (preprint)

Introduction: Coronavirus disease (COVID-19) is a global infectious disease with a large burden of illness and high healthcare costs.Objectives: This study aimed to compare clinical features among adult COVID-19 patients in different age groups.Methods: Laboratory-confirmed adult COVID-19 infection cases between Dec 31, 2019 to March 8, 2020 obtained from Neighboring Cities. Patients were divided into five age groups: age＜30, 30-40, 40-50, 50-65, ≥65 y (elderly). Age, sex, history of chronic disease and epidemiology, symptoms, laboratory tests, and outcomes were compared among different age groups. Binary logistic regression analysis was conducted to evaluate associated factors for severe or critical type.Results: We studied 299 cases. Median (IQR) age was 44 (34,54) and 158 (53%) were male. Percent of bilateral involvement on chest radiographs was increased significantly with older age (p = 0.005). 53.3% of 30-40 years, 50% of 40-50 years, 36.6% of ＜30 years and 36.2% of 50-60 years were imported case, none of the elderly were imported case. Among all the observed symptoms, only symptom of dyspnea was significantly different between the elderly group and other groups (p < 0.001). Proportion of severe or critical type was 2.4%, 5.3%, 9.5%, 14.5%, and 35% in patients with age＜30, 30-40, 40-50, 50-65, ≥65 (p < 0.001), respectively.  At this point, ICU admission rate, ARDS and shock rate and on medical treatment rate was increased especially in patients ≥65 years. 285 patients (95.3%) were cured and discharged, 12 patients (4.0%) were still on medical treatment in hospital. There were 2 (0.67%) deaths; these occurred among persons ≥65 y (p < 0.001). Old age, high HR on admission, high respiratory rate on admission, and history of chronic heart disease were independently associated with severe or critical .Conclusions: Proportion of severe or critical type increased with old age groups. Adults with old age and high HR, R rate in admission and history of chronic heart disease were associated with severe or critical type in COVID-19.